Complement 3(+)-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia considered to be the potential neurotoxic species at late disease stages. Recent investigations...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Hartmann, Kristin, Sepulveda-Falla, Diego, Rose, Indigo V. L., Madore, Charlotte, Muth, Christiane, Matschke, Jakob, Butovsky, Oleg, Liddelow, Shane, Glatzel, Markus, Krasemann, Susanne
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530067/
https://ncbi.nlm.nih.gov/pubmed/31118110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0735-1
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