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Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

BACKGROUND: Immune checkpoint inhibitors are not effective for pancreatic ductal adenocarcinoma (PDAC) as single agents. Vaccine therapy may sensitize PDACs to checkpoint inhibitor treatments. Annexin A2 (ANXA2) is a pro-metastasis protein, previously identified as a relevant PDAC antigen that is ex...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Immunother Cancer
Main Authors: Kim, Victoria M., Blair, Alex B., Lauer, Peter, Foley, Kelly, Che, Xu, Soares, Kevin, Xia, Tao, Muth, Stephen T., Kleponis, Jennifer, Armstrong, Todd D., Wolfgang, Christopher L., Jaffee, Elizabeth M., Brockstedt, Dirk, Zheng, Lei
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529991/
https://ncbi.nlm.nih.gov/pubmed/31113479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0601-5
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