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Small‐molecule peptides inhibit Z α(1)‐antitrypsin polymerization
The Z variant of α(1)‐antitrypsin (AT) polymerizes within the liver and gives rise to liver cirrhosis and the associated plasma deficiency leads to emphysema. In this work, a combinatorial approach based on the inhibitory mechanism of α(1)‐AT was developed to arrest its pathogenic polymerization. On...
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| Опубликовано в: : | J Cell Mol Med |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6529975/ https://ncbi.nlm.nih.gov/pubmed/19120695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00608.x |
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