Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy

Injury of peripheral nerves may quickly induce severe pain, but the mechanism remains obscure. We observed a rapid onset of spontaneous pain and evoked pain hypersensitivity after acute transection of the L5 spinal nerve (SNT) in awake rats. The outburst of pain was associated with a rapid developme...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Zhiyong, Wang, Tao, Fang, Yehong, Luo, Dan, Anderson, Michael, Huang, Qian, He, Shaoqiu, Song, Xiaodan, Cui, Huan, Dong, Xinzhong, Xie, Yikuan, Guan, Yun, Ma, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529466/
https://ncbi.nlm.nih.gov/pubmed/31113988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44172-9
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