Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans

Adipose tissue inflammation is a reproducible feature of obesity and obesity-linked insulin resistance. Although sirtuin 6 (Sirt6) deficiency has previously been implicated in diet-induced obesity and systemic insulin resistance, the adipocyte-specific role of Sirt6 in the regulation of adipose tiss...

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Publicado no:Exp Mol Med
Main Authors: Song, Mi-Young, Kim, Sang Hoon, Ryoo, Ga-Hee, Kim, Mi-Kyung, Cha, Hye-Na, Park, So-Young, Hwang, Hong Pil, Yu, Hee Chul, Bae, Eun Ju, Park, Byung-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529411/
https://ncbi.nlm.nih.gov/pubmed/31113929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0256-9
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