Challenge model of TNF(α) turnover at varying LPS and drug provocations

A mechanism-based biomarker model of TNF(α)-response, including different external provocations of LPS challenge and test compound intervention, was developed. The model contained system properties (such as k(t), k(out)), challenge characteristics (such as k(s), k(LPS), K(m, LPS), S(max), SC(50)) an...

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Bibliographic Details
Published in:J Pharmacokinet Pharmacodyn
Main Authors: Held, Felix, Hoppe, Edmund, Cvijovic, Marija, Jirstrand, Mats, Gabrielsson, Johan
Format: Artigo
Language:Inglês
Published: Springer US 2019
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529397/
https://ncbi.nlm.nih.gov/pubmed/30778719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-019-09622-x
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