Challenge model of TNF(α) turnover at varying LPS and drug provocations

A mechanism-based biomarker model of TNF(α)-response, including different external provocations of LPS challenge and test compound intervention, was developed. The model contained system properties (such as k(t), k(out)), challenge characteristics (such as k(s), k(LPS), K(m, LPS), S(max), SC(50)) an...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Pharmacokinet Pharmacodyn
Main Authors: Held, Felix, Hoppe, Edmund, Cvijovic, Marija, Jirstrand, Mats, Gabrielsson, Johan
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2019
Assuntos:
Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529397/
https://ncbi.nlm.nih.gov/pubmed/30778719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-019-09622-x
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares