Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis and intestinal inflammation

Receptor Interacting Serine/Threonine Kinase 1 (RIPK1) is a master regulator of signaling pathways leading to inflammation and cell death and is of medical interest as a drug target. Here, we report four patients from three unrelated families with complete RIPK1 deficiency caused by rare homozygous...

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Publicado no:Science
Main Authors: Cuchet-Lourenço, Delphine, Eletto, Davide, Wu, Changxin, Plagnol, Vincent, Papapietro, Olivier, Curtis, James, Ceron-Gutierrez, Lourdes, Bacon, Chris M., Hackett, Scott, Alsaleem, Badr, Maes, Mailis, Gaspar, Miguel, Alisaac, Ali, Goss, Emma, AlIdrissi, Eman, Siegmund, Daniela, Wajant, Harald, Kumararatne, Dinakantha, AlZahrani, Mofareh S., Arkwright, Peter D., Abinun, Mario, Doffinger, Rainer, Nejentsev, Sergey
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529353/
https://ncbi.nlm.nih.gov/pubmed/30026316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar2641
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