Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation

Very little is known about how lipid signaling regulates intima hyperplasia after vascular injury. Herein, we report that deletion and pharmacological inhibition of phospholipase D (PLD)2, which generates the signaling lipid phosphatidic acid (PA), reduced neointimal formation in the mouse carotid a...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Wang, Ziqing, Cai, Ming, Tay, Li Wei Rachel, Zhang, Feng, Wu, Ping, Huynh, Anh, Cao, Xiumei, Di Paolo, Gilbert, Peng, Junmin, Milewicz, Dianna M., Du, Guangwei
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529346/
https://ncbi.nlm.nih.gov/pubmed/30811216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800390RR
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