Binding of PLD2-generated phosphatidic acid to KIF5B promotes MT1-MMP surface trafficking and lung metastasis of mouse breast cancer cells

Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model. PLD2 promotes local invas...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Wang, Ziqing, Zhang, Feng, He, Jingquan, Wu, Ping, Tay, Li Wei Rachel, Cai, Ming, Nian, Weiqi, Weng, Yuanyuan, Qin, Li, Chang, Jeffrey T, McIntire, Laura B, Di Paolo, Gilbert, Xu, Jianming, Peng, Junmin, Du, Guangwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663201/
https://ncbi.nlm.nih.gov/pubmed/29033361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.09.012
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