Binding of PLD2-generated phosphatidic acid to KIF5B promotes MT1-MMP surface trafficking and lung metastasis of mouse breast cancer cells

Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model. PLD2 promotes local invas...

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Publicat a:Dev Cell
Autors principals: Wang, Ziqing, Zhang, Feng, He, Jingquan, Wu, Ping, Tay, Li Wei Rachel, Cai, Ming, Nian, Weiqi, Weng, Yuanyuan, Qin, Li, Chang, Jeffrey T, McIntire, Laura B, Di Paolo, Gilbert, Xu, Jianming, Peng, Junmin, Du, Guangwei
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663201/
https://ncbi.nlm.nih.gov/pubmed/29033361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.09.012
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