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A new IRF-1-driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cells and weakens protection against viral infection
Early life immune responses are deficient in T helper 1 (Th1) lymphocytes which compromises neonatal vaccination. We found that IL-4 and IL-13 engage a developmentally expressed IL-4Rα/IL-13Rα1 heteroreceptor (HR) to endow interferon regulatory factor 1 (IRF-1) with apoptotic functions which redirec...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6529256/ https://ncbi.nlm.nih.gov/pubmed/30996000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800943 |
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