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Adenylyl cyclases and TRPV4 mediate Ca(2+)/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes

Bone adapts to physical forces and this process is dependent on osteocyte mechanotransduction. One way osteocytes sense mechanical stimulation is through the primary cilium, a sensory organelle that triggers intracellular signaling cascades in response to fluid shear. Our lab previously determined t...

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Pubblicato in:J Mol Biochem
Autori principali: Moore, Emily R, Ryu, Han Seul, Zhu, Ya Xing, Jacobs, Christopher R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529196/
https://ncbi.nlm.nih.gov/pubmed/31123666
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