Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling

Receptor clustering on cell membrane is critical in the signaling of many immunoreceptors and this mechanism has previously been attributed to the extracellular and/or the intracellular interactions. Here, we report an unexpected finding that for death receptor 5 (DR5), a receptor in the tumor necro...

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Veröffentlicht in:Cell
Hauptverfasser: Pan, Liqiang, Fu, Tian-Min, Zhao, Wenbin, Zhao, Linlin, Chen, Wen, Qiu, Chixiao, Liu, Wenhui, Liu, Zhijun, Piai, Alessandro, Fu, Qingshan, Chen, Shuqing, Wu, Hao, Chou, James J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529188/
https://ncbi.nlm.nih.gov/pubmed/30827683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.001
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