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Modified ToxT inhibitor reduces Vibrio cholerae virulence in vivo

We have previously designed and synthesized small-molecule inhibitors that reduce Vibrio cholerae virulence in vitro by targeting the transcription factor ToxT. Here we report the synthesis and biological activity of derivatives of our previous bicyclic, fatty acid-like inhibitors. All of the synthe...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Woodbrey, Anne K., Onyango, Evans O., Kovacikova, Gabriela, Kull, F. Jon, Gribble, Gordon W.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528795/
https://ncbi.nlm.nih.gov/pubmed/30160100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00667
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