TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer

BACKGROUND: Impairment of natural killer (NK) cell activity is an important mechanism of tumor immunoevasion. T cell immunoglobulin domain and mucin domain-3 (Tim-3) is an activation-induced inhibitory molecule, inducing effector lymphocyte exhaustion in chronic viral infection and cancers. However,...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Transl Med
Main Authors: Zheng, Yujia, Li, Yu, Lian, Jingyao, Yang, Huiyun, Li, Feng, Zhao, Song, Qi, Yu, Zhang, Yi, Huang, Lan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528366/
https://ncbi.nlm.nih.gov/pubmed/31109341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1917-0
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