Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington’s Disease Mice

Huntington’s disease (HD) is a heritable neurological disorder that affects cognitive and motor performance in patients carrying the mutated huntingtin (HTT) gene. In mouse models of HD, previous reports showed a significant increase in spontaneous GABA(A) receptor-mediated synaptic activity in stri...

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Detalles Bibliográficos
Publicado en:Front Synaptic Neurosci
Autores principales: Holley, Sandra M., Galvan, Laurie, Kamdjou, Talia, Dong, Ashley, Levine, Michael S., Cepeda, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527892/
https://ncbi.nlm.nih.gov/pubmed/31139071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsyn.2019.00014
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