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Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4

Cytochrome P450 (CYP) 3A4 is a major contributor to hepatic drug and xenobiotic metabolism in human adults. The related enzyme CYP3A5 is also expressed in adult liver and has broader age and tissue distributions. However, CYP3A5 expression is low in most Caucasians because of the prevalence of an al...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Hsu, Mei-Hui, Johnson, Eric F.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527174/
https://ncbi.nlm.nih.gov/pubmed/30926609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007928
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