Functional complementation reveals that 9 of the 13 human V-ATPase subunits can functionally substitute for their yeast orthologs

Vacuolar-type H(+)-ATPase (V-ATPase) is a highly conserved proton pump responsible for acidification of intracellular organelles and potential drug target. It is a multisubunit complex comprising a cytoplasmic V(1) domain responsible for ATP hydrolysis and a membrane-embedded V(o) domain that contri...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Abe, Michiko, Saito, Mayu, Tsukahara, Ayana, Shiokawa, Shuka, Ueno, Kazuma, Shimamura, Hiroki, Nagano, Makoto, Toshima, Junko Y., Toshima, Jiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527166/
https://ncbi.nlm.nih.gov/pubmed/30952699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006192
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