The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress

Endoplasmic reticulum (ER) stress is thought to activate autophagy via unfolded protein response (UPR)-mediated transcriptional up-regulation of autophagy machinery components and modulation of microtubule-associated protein 1 light chain 3 (LC3). The upstream UPR constituents pancreatic EIF2-α kina...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Luhr, Morten, Torgersen, Maria Lyngaas, Szalai, Paula, Hashim, Adnan, Brech, Andreas, Staerk, Judith, Engedal, Nikolai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527152/
https://ncbi.nlm.nih.gov/pubmed/30926605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002829
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