A Platform for the Discovery of New Macrolide Antibiotics

The chemical modification of structurally complex fermentation products, a process known as semisynthesis, has been an important tool for the discovery and manufacture of antibiotics for the treatment of various infectious diseases. However, many of the therapeutics obtained in this way are no longe...

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Veröffentlicht in:Nature
Hauptverfasser: Seiple, Ian B., Zhang, Ziyang, Jakubec, Pavol, Langlois-Mercier, Audrey, Wright, Peter M., Hog, Daniel T., Yabu, Kazuo, Allu, Senkara Rao, Fukuzaki, Takehiro, Carlsen, Peter N., Kitamura, Yoshiaki, Zhou, Xiang, Condakes, Matthew L., Szczypiński, Filip T., Green, William D., Myers, Andrew G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526944/
https://ncbi.nlm.nih.gov/pubmed/27193679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17967
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