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Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein
Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propagates and spreads throughout the brain ultimately resulting in...
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| Veröffentlicht in: | Acta Neuropathol Commun |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6526619/ https://ncbi.nlm.nih.gov/pubmed/31109379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0703-9 |
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