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Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip

We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical cues and morphogen gradients influence intestinal morphogenesis. Both human intestinal Caco-2 and intestinal organoid-derived primary epithelia...

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Bibliografiske detaljer
Udgivet i:iScience
Main Authors: Shin, Woojung, Hinojosa, Christopher D., Ingber, Donald E., Kim, Hyun Jung
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526295/
https://ncbi.nlm.nih.gov/pubmed/31108394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.04.037
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