Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α

Background: Liver cancer stem cells (LCSCs) are responsible for the initiation, progression and chemoresistance of liver cancer. However, no agent targeting LCSC is available in the clinic to date. Here, we investigated the effects of targeting protein arginine methyltransferase 5 (PRMT5), an epigen...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zheng, Bai-Nan, Ding, Chen-Hong, Chen, Shi-Jie, Zhu, Kongkai, Shao, Jingwei, Feng, Jifeng, Xu, Wen-Ping, Cai, Ling-Yan, Zhu, Chang-Peng, Duan, Wenhu, Ding, Jin, Zhang, Xin, Luo, Cheng, Xie, Wei-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525986/
https://ncbi.nlm.nih.gov/pubmed/31131056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32344
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