Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

BACKGROUND: Hypoxia-ischemia (HI) during the perinatal period is one of the most common causes of acute mortality and chronic neurologic morbidity. Hydrogen-rich saline (HS) treatment in neonatal mice has been reported to alleviate brain injury following HI, but the mechanisms involved are not known...

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Gepubliceerd in:J Neuroinflammation
Hoofdauteurs: Chu, Xili, Cao, Lili, Yu, Zhuoya, Xin, Danqing, Li, Tingting, Ma, Weiwei, Zhou, Xin, Chen, Wenqiang, Liu, Dexiang, Wang, Zhen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525972/
https://ncbi.nlm.nih.gov/pubmed/31103039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1488-2
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