PGE(2) signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia

The inflammatory prostaglandin E2 (PGE(2)) EP2 receptor is a master suppressor of beneficial microglial function, and myeloid EP2 signaling ablation reduces pathology in models of inflammatory neurodegeneration. Here, we investigated the role of PGE(2) EP2 signaling in a model of stroke in which the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Qingkun, Liang, Xibin, Wang, Qian, Wilson, Edward N., Lam, Rachel, Wang, Jing, Kong, William, Tsai, Connie, Pan, Tingting, Larkin, Paul B., Shamloo, Mehrdad, Andreasson, Katrin I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525498/
https://ncbi.nlm.nih.gov/pubmed/31036664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818544116
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