Iron regulatory protein 2 modulates the switch from aerobic glycolysis to oxidative phosphorylation in mouse embryonic fibroblasts

The importance of the role of iron regulatory proteins (IRPs) in mitochondrial iron homeostasis and function has been raised. To understand how an IRP affects mitochondrial function, we used globally Irp2-depleted mouse embryonic fibroblasts (MEFs) and found that Irp2 ablation significantly induced...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Li, Huihui, Liu, Yutong, Shang, Longcheng, Cai, Jing, Wu, Jing, Zhang, Wei, Pu, Xiaojiang, Dong, Weichen, Qiao, Tong, Li, Kuanyu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525483/
https://ncbi.nlm.nih.gov/pubmed/31040213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820051116
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