BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway

BACKGROUND: Cancer stem cells (CSCs), drug-resistant cancer cell subsets, are known to be responsible for tumor metastasis and relapse. The JAK/STAT pathway, activated by SH2 domain, is known to regulate the tumor growth in gastric cancer (GC). Now, this study was designed to examine whether BMX-ARH...

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Publicat a:Cancer Cell Int
Autors principals: Xu, Xiao-Feng, Gao, Feng, Wang, Jian-Jiang, Long, Cong, Chen, Xing, Tao, Lan, Yang, Liu, Ding, Li, Ji, Yong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Primary Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525346/
https://ncbi.nlm.nih.gov/pubmed/31130822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0847-5
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