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The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors

The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. To address the role of endothelial cell Shb gene for B16F10 melanoma immune responses, tamoxifen-injected Cdh5-CreERT2/WT and Cdh5-CreERT2/Shb(flox/fl...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: He, Qi, Li, Xiujuan, Singh, Kailash, Luo, Zhengkang, Meija-Cordova, Mariela, Jamalpour, Maria, Lindahl, Björn, Kriz, Vitezslav, Vuolteenaho, Reetta, Ulvmar, Maria, Welsh, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525206/
https://ncbi.nlm.nih.gov/pubmed/31101877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44039-z
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