Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a devastating disease with poor prognosis and limited therapeutic options. We screened for pathways that may be responsible for the abnormal phenotype of pulmonary arterial smooth muscle cells (PASMCs), a major contributor of PAH pathobiology, and identified...

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Udgivet i:Nat Commun
Main Authors: Weiss, Astrid, Neubauer, Moritz Christian, Yerabolu, Dinesh, Kojonazarov, Baktybek, Schlueter, Beate Christiane, Neubert, Lavinia, Jonigk, Danny, Baal, Nelli, Ruppert, Clemens, Dorfmuller, Peter, Pullamsetti, Soni Savai, Weissmann, Norbert, Ghofrani, Hossein-Ardeschir, Grimminger, Friedrich, Seeger, Werner, Schermuly, Ralph Theo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525202/
https://ncbi.nlm.nih.gov/pubmed/31101827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10135-x
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