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Dynamics of Replication Fork Progression Following Helicase–Polymerase Uncoupling in Eukaryotes
Leading-strand polymerase stalling at DNA damage impairs replication fork progression. Using biochemical approaches, we show this arises due to both slower template unwinding following helicase–polymerase uncoupling and establishment of prolonged stalled fork structures. Fork slowing and stalling oc...
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| Udgivet i: | J Mol Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525111/ https://ncbi.nlm.nih.gov/pubmed/30894292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.03.011 |
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