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Dynamics of Replication Fork Progression Following Helicase–Polymerase Uncoupling in Eukaryotes
Leading-strand polymerase stalling at DNA damage impairs replication fork progression. Using biochemical approaches, we show this arises due to both slower template unwinding following helicase–polymerase uncoupling and establishment of prolonged stalled fork structures. Fork slowing and stalling oc...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525111/ https://ncbi.nlm.nih.gov/pubmed/30894292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.03.011 |
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