Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland

Obesity is a highly prevalent and modifiable breast cancer risk factor. While the role of obesity in fueling breast cancer progression is well established, the mechanisms linking obesity to breast cancer initiation are poorly understood. A hallmark of breast cancer initiation is the disruption of ap...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Tenvooren, Iliana, Jenks, Mónica Z., Rashid, Hamza, Cook, Katherine L., Muhlemann, Joëlle K., Sistrunk, Christopher, Holmes, Julia, Wang, Kevin, Bonin, Keith, Hodges, Kurt, Lo, Hui-Wen, Shaikh, Ayaz, Camarillo, Ignacio G., Lelièvre, Sophie A., Seewaldt, Victoria, Vidi, Pierre-Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525037/
https://ncbi.nlm.nih.gov/pubmed/30670780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0687-8
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