Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland

Obesity is a highly prevalent and modifiable breast cancer risk factor. While the role of obesity in fueling breast cancer progression is well established, the mechanisms linking obesity to breast cancer initiation are poorly understood. A hallmark of breast cancer initiation is the disruption of ap...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Tenvooren, Iliana, Jenks, Mónica Z., Rashid, Hamza, Cook, Katherine L., Muhlemann, Joëlle K., Sistrunk, Christopher, Holmes, Julia, Wang, Kevin, Bonin, Keith, Hodges, Kurt, Lo, Hui-Wen, Shaikh, Ayaz, Camarillo, Ignacio G., Lelièvre, Sophie A., Seewaldt, Victoria, Vidi, Pierre-Alexandre
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525037/
https://ncbi.nlm.nih.gov/pubmed/30670780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0687-8
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