Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions

Pregnancy causes a series of cellular and molecular changes in mammary epithelial cells (MECs) of female adults. In addition, pregnancy can also modify the predisposition of rodent and human MECs to initiate oncogenesis. Here, we investigate how pregnancy reprograms enhancer chromatin in the mammary...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Feigman, Mary J., Moss, Matthew A., Chen, Chen, Cyrill, Samantha L., Ciccone, Michael F., Trousdell, Marygrace C., Yang, Shih-Ting, Frey, Wesley D., Wilkinson, John E., dos Santos, Camila O.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253414/
https://ncbi.nlm.nih.gov/pubmed/32461571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16479-z
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