Mechanistic Basis for the Differential Effects of Rivaroxaban and Apixaban on Global Tests of Coagulation

Rivaroxaban and apixaban are both small molecules that reversibly inhibit factor Xa. Compared with rivaroxaban, apixaban has minimal effects on the prothrombin time and activated partial thromboplastin time. To investigate this phenomenon, we used a factor Xa-directed substrate in a buffer system. A...

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Detalhes bibliográficos
Publicado no:TH Open
Main Authors: Kim, Paul Y., Yeh, Calvin H., Dale, Brian J., Leslie, Beverly A., Stafford, Alan R., Fredenburgh, James C., Hirsh, Jack, Weitz, Jeffrey I.
Formato: Artigo
Idioma:Inglês
Publicado em: Georg Thieme Verlag KG 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524873/
https://ncbi.nlm.nih.gov/pubmed/31249942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1649507
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