Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms

Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic meta-analyses of 24 age-related phenotypes dealing with such evolutionary uncertainty and leveragin...

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Bibliographic Details
Published in:Front Genet
Main Authors: Kulminski, Alexander M., Loika, Yury, Huang, Jian, Arbeev, Konstantin G., Bagley, Olivia, Ukraintseva, Svetlana, Yashin, Anatoliy I., Culminskaya, Irina
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524409/
https://ncbi.nlm.nih.gov/pubmed/31134135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00433
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