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Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder that exhibits aberrant protein aggregation and mitochondrial dysfunction. Ndi1, the yeast mitochondrial NADH dehydrogenase (complex I) enzyme, is a single subunit, internal matrix-facing protein. Previous studies have shown that Ndi1 expressio...

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Bibliografske podrobnosti
izdano v:Biomolecules
Main Authors: Cronin-Furman, Emily N., Barber-Singh, Jennifer, Bergquist, Kristen E., Yagi, Takao, Trimmer, Patricia A.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523508/
https://ncbi.nlm.nih.gov/pubmed/30934776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9040119
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