Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells

Obesity is characterized by chronic low-grade inflammation that contributes to development of cardiometabolic disorders. Cannabinoid receptor 1 (CB1) antagonists attenuate diet-induced obesity (DIO) and related inflammation, although the precise anti-inflammatory mechanisms involved have not been fu...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Miranda, Kathryn, Mehrpouya-Bahrami, Pegah, Nagarkatti, Prakash S., Nagarkatti, Mitzi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523050/
https://ncbi.nlm.nih.gov/pubmed/31134094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01049
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