Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5

Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to confirm the localization of proteins in retinal cell types and to test transduction and expression patterns of gene therapy vectors. Here, we compared the onset of CRB protein expression in human fetal retina with hu...

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發表在:Stem Cell Reports
Main Authors: Quinn, Peter M., Buck, Thilo M., Mulder, Aat A., Ohonin, Charlotte, Alves, C. Henrique, Vos, Rogier M., Bialecka, Monika, van Herwaarden, Tessa, van Dijk, Elon H.C., Talib, Mays, Freund, Christian, Mikkers, Harald M.M., Hoeben, Rob C., Goumans, Marie-José, Boon, Camiel J.F., Koster, Abraham J., Chuva de Sousa Lopes, Susana M., Jost, Carolina R., Wijnholds, Jan
格式: Artigo
語言:Inglês
出版: Elsevier 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522954/
https://ncbi.nlm.nih.gov/pubmed/30956116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.03.002
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