MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt signalling to modulate stem cell homeostasis in CRC currently remains poorly understood. Using large-scale compound screens i...

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Publicado no:Nat Commun
Main Authors: Zhan, Tianzuo, Ambrosi, Giulia, Wandmacher, Anna Maxi, Rauscher, Benedikt, Betge, Johannes, Rindtorff, Niklas, Häussler, Ragna S., Hinsenkamp, Isabel, Bamberg, Leonhard, Hessling, Bernd, Müller-Decker, Karin, Erdmann, Gerrit, Burgermeister, Elke, Ebert, Matthias P., Boutros, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522484/
https://ncbi.nlm.nih.gov/pubmed/31097693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09898-0
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