MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt signalling to modulate stem cell homeostasis in CRC currently remains poorly understood. Using large-scale compound screens i...

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Vydáno v:Nat Commun
Hlavní autoři: Zhan, Tianzuo, Ambrosi, Giulia, Wandmacher, Anna Maxi, Rauscher, Benedikt, Betge, Johannes, Rindtorff, Niklas, Häussler, Ragna S., Hinsenkamp, Isabel, Bamberg, Leonhard, Hessling, Bernd, Müller-Decker, Karin, Erdmann, Gerrit, Burgermeister, Elke, Ebert, Matthias P., Boutros, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522484/
https://ncbi.nlm.nih.gov/pubmed/31097693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09898-0
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