Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T cells in Trastuzumab-treated Patients using Imaging Mass Cytometry

PURPOSE: Imaging Mass Cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ICD/ECD, cytotoxic T cell infiltration and other structural and signaling prote...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Cancer Res
Prif Awduron: Carvajal-Hausdorf, Daniel E., Patsenker, Jonathan, Stanton, Kelly, Espindola, Franz Villarroel, Esch, Amanda, Montgomery, Ruth R., Psyrri, Amanda, Kalogeras, Konstantine T., Kotoula, Vasiliki, Fountzilas, George, Schalper, Kurt A., Kluger, Yuval, Rimm, David L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522272/
https://ncbi.nlm.nih.gov/pubmed/30796036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2599
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