Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T cells in Trastuzumab-treated Patients using Imaging Mass Cytometry

PURPOSE: Imaging Mass Cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ICD/ECD, cytotoxic T cell infiltration and other structural and signaling prote...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Carvajal-Hausdorf, Daniel E., Patsenker, Jonathan, Stanton, Kelly, Espindola, Franz Villarroel, Esch, Amanda, Montgomery, Ruth R., Psyrri, Amanda, Kalogeras, Konstantine T., Kotoula, Vasiliki, Fountzilas, George, Schalper, Kurt A., Kluger, Yuval, Rimm, David L.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522272/
https://ncbi.nlm.nih.gov/pubmed/30796036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2599
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