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Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy

The transcription factor Oct1/Pou2f1 promotes poised gene expression states, mitotic stability, glycolytic metabolism and other characteristics of stem cell potency. To determine the effect of Oct1 loss on stem cell maintenance and malignancy, we deleted Oct1 in two different mouse gut stem cell com...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Vázquez-Arreguín, Karina, Bensard, Claire, Schell, John C., Swanson, Eric, Chen, Xinjian, Rutter, Jared, Tantin, Dean
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522070/
https://ncbi.nlm.nih.gov/pubmed/31059499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007687
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