Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein 176B (TMEM176B) contributes to CD8(+) T cell-mediated tumor growth inhibiti...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Segovia, Mercedes, Russo, Sofia, Jeldres, Mathias, Mahmoud, Yamil D., Perez, Valentina, Duhalde, Maite, Charnet, Pierre, Rousset, Matthieu, Victoria, Sabina, Veigas, Florencia, Louvet, Cédric, Vanhove, Bernard, Floto, R. Andrés, Anegon, Ignacio, Cuturi, Maria Cristina, Girotti, M. Romina, Rabinovich, Gabriel A., Hill, Marcelo
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521897/
https://ncbi.nlm.nih.gov/pubmed/31085177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.04.003
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