Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein 176B (TMEM176B) contributes to CD8(+) T cell-mediated tumor growth inhibiti...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Segovia, Mercedes, Russo, Sofia, Jeldres, Mathias, Mahmoud, Yamil D., Perez, Valentina, Duhalde, Maite, Charnet, Pierre, Rousset, Matthieu, Victoria, Sabina, Veigas, Florencia, Louvet, Cédric, Vanhove, Bernard, Floto, R. Andrés, Anegon, Ignacio, Cuturi, Maria Cristina, Girotti, M. Romina, Rabinovich, Gabriel A., Hill, Marcelo
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521897/
https://ncbi.nlm.nih.gov/pubmed/31085177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.04.003
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