β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis

Hepatoblastoma (HB), the most common pediatric primary liver neoplasm, shows nuclear localization of β-catenin and yes-associated protein 1 (YAP1) in almost 80% of the cases. Co-expression of constitutively active S127A-YAP1 and ΔN90 deletion-mutant β-catenin (YAP1–ΔN90-β-catenin) causes HB in mice....

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Pubblicato in:Am J Pathol
Autori principali: Min, Qian, Molina, Laura, Li, Jing, Adebayo Michael, Adeola O., Russell, Jacquelyn O., Preziosi, Morgan E., Singh, Sucha, Poddar, Minakshi, Matz-Soja, Madlen, Ranganathan, Sarangarajan, Bell, Aaron W., Gebhardt, Rolf, Gaunitz, Frank, Yu, Jinming, Tao, Junyan, Monga, Satdarshan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521893/
https://ncbi.nlm.nih.gov/pubmed/30794807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.02.002
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