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Exploring Structural Parameters for Pretargeting Radioligand Optimization

Pretargeting offers a way to enhance target specificity while reducing off-target radiation dose to healthy tissue during payload delivery. We recently reported the development of an (18)F-based pretargeting strategy predicated on the inverse electron demand Diels-Alder reaction as well as the use o...

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Detalles Bibliográficos
Publicado en:J Med Chem
Main Authors: Meyer, Jan-Philip, Kozlowski, Paul, Jackson, James, Cunanan, Kristen M., Adumeau, Pierre, Dilling, Thomas R., Zeglis, Brian M., Lewis, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521719/
https://ncbi.nlm.nih.gov/pubmed/28857566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01108
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