A Validated HPLC-MS/MS Method for Simultaneous Determination of Militarine and Its Three Metabolites in Rat Plasma: Application to a Pharmacokinetic Study

A rapid, reliable, and sensitive HPLC-electrospray ionization-tandem mass spectrometry (HPLC-MS/MS) method was established and validated for simultaneous determination of militarine and its three metabolites (gastrodin, α-isobutylmalic acid, and gymnoside I) in rat plasma. Plasma was acidified with...

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Detalhes bibliográficos
Publicado no:Evid Based Complement Alternat Med
Main Authors: Sun, Hui-Yuan, Zheng, Lin, Gong, Zi-Peng, Li, Yue-Ting, Yang, Chang, Pan, Jie, Wang, Yong-Lin, Wang, Ai-Min, Li, Yong-Jun, Huang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521569/
https://ncbi.nlm.nih.gov/pubmed/31186657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2371784
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