Assessment of a High Sensitivity Method for Identification of IDH1 R132x Mutations in Tumors and Plasma of Intrahepatic Cholangiocarcinoma Patients

Hotspot codon 132 mutations (R132xIDH1m) are frequent in intrahepatic cholangiocarcinoma (ICC), are druggable by anti-IDH1m agents, and could represent a marker of disease progression. Developing an assay to identify R132xIDH1m would provide a useful tool to select patients benefitting from targeted...

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Gepubliceerd in:Cancers (Basel)
Hoofdauteurs: Peraldo-Neia, Caterina, Scatolini, Maria, Grosso, Enrico, Lombardi, Pasquale, Filippi, Roberto, Raggi, Chiara, Marchiò, Caterina, Cavalloni, Giuliana, Aglietta, Massimo, Leone, Francesco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521091/
https://ncbi.nlm.nih.gov/pubmed/30935002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040454
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