Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance

A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to eluci...

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Bibliographische Detailangaben
Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Kulkoyluoglu-Cotul, Eylem, Smith, Brandi Patrice, Wrobel, Kinga, Chen Zhao, Yiru, Chen, Karen Lee Ann, Hieronymi, Kadriye, Imir, Ozan Berk, Duong, Kevin, O’Callaghan, Caitlin, Mehta, Aditi, Sahoo, Sunati, Haley, Barbara, Chang, Hua, Landesman, Yosef, Madak-Erdogan, Zeynep
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520695/
https://ncbi.nlm.nih.gov/pubmed/30987380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040479
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